New system can identify drugs to target 'undruggable' enzymes critical in many diseases

A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly 'undruggable'. The study demonstrated the capabilities of the new system by identifying a molecule that could successfully target a phosphatase to reduce the accumulation of Huntington's disease-associated proteins in the brains of mice.

https://www.sciencedaily.com/releases/2018/07/180726160956.htm